HCG & Gonadotropin Therapy

Complete HCG Protocol Guide for Post-Cycle Recovery

Protocol Element Details & Best Practices
Purpose of HCG in PCT – Mimics LH (Luteinizing Hormone), directly stimulating the testes to produce endogenous testosterone.
– Helps prevent or reverse testicular atrophy during or after steroid use.
– Can bridge periods between cycle cessation and traditional SERM-based PCT (e.g., Clomid, Nolvadex).
When to Use – During cycle (“on-cycle support”): Low-dose HCG can prevent shutdown and maintain testicular function.
– Post cycle (beginning of PCT): Used to “prime” the testes before SERM therapy, especially after extended cycles or visible atrophy.
– Not usually recommended during SERM phase or prolonged use (due to desensitization risk).
Standard HCG Dosing – On-cycle support: 250–500 IU twice weekly
– PCT “blast”: 1,000–2,000 IU every other day for 2–3 weeks (most common for severe suppression or atrophy)
– Transition to SERM PCT: Stop HCG 3–4 days before starting Clomid/Nolvadex to avoid estrogen spikes.
– Maximum duration: Use HCG for 2–3 weeks at a time to avoid Leydig cell desensitization.
Timing & Administration – Begin HCG at least 5–10 days after the last steroid injection (for long-ester compounds), or 2–3 days after last oral/short ester.
– Start SERM-based PCT (Clomid/Nolvadex) 3–4 days after last HCG injection.
– HCG is administered via subcutaneous or intramuscular injection. Best injected on an empty stomach for consistency.

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